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Some related articles:

Reward processing:

Set of brain mechanisms that underlie the processes of pleasure, motivation and decision-making

axis carriers

Benjamin Rolland.jpg

Professor Benjamin


Guillaume Sescousse.jpg

Doctor Guillaume


Effects of acute ethanol and/or diazepam exposure on immediate and delayed hippocampal metabolite levels in rats anesthetized with isoflurane. 

Carton L, Auger F, Laloux C, Durieux N, Kyheng M, Potey C, Bergeron S, Rolland B, Deguil J, Bordet R. Fundam Clin Pharmacol. 2022 Feb 1. doi: 10.1111/fcp.12764. 

Tobacco-induced sleep disturbances: A systematic review and meta-analysis. 

Catoire S, Nourredine M, Lefebvre S, Couraud S, Gronfier C, Rey R, Peter-Derex L, Geoffroy PA, Rolland B. Sleep Med Rev. 2021 Dec;60:101544.


Hostile attributional bias in severe alcohol use disorder. 

Pabst A, Peyroux E, Rolland B, de Timary P, Maurage P. J Psychiatr Res. 2020 Oct;129:176-180.

Respective influence of current alcohol consumption and duration of heavy drinking on brain morphological alterations in alcohol use disorder. 

Rolland B, Dricot L, Creupelandt C, Maurage P, De Timary P. Addict Biol. 2020 Mar;25(2):e12751.


Therapeutic Prospects of Cannabidiol for Alcohol Use Disorder and Alcohol-Related Damages on the Liver and the Brain. 

De Ternay J, Naassila M, Nourredine M, Louvet A, Bailly F, Sescousse G, Maurage P, Cottencin O, Carrieri PM, Rolland B. Front Pharmacol. 2019 May 31;10:627.


A Patient-Tailored Evidence-Based Approach for Developing Early Neuropsychological Training Programs in Addiction Settings. 

Rolland B, D'Hondt F, Montègue S, Brion M, Peyron E, D'Aviau de Ternay J, de Timary P, Nourredine M, Maurage P.Neuropsychol Rev. 2019 Mar;29(1):103-115.

Pathological gambling:


Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction.

van Holst RJ*, Sescousse G*, Janssen LK, Janssen M, Berry AS, Jagust WJ, Cools R.Biol Psychiatry (2018) 83(12): 1036-1043

Spontaneous eye blink rate and dopamine synthesis capacity: preliminary evidence for an absence of positive correlation.Sescousse G*, Ligneul R*, van Holst RJ*, Janssen LK, de Boer F, Janssen M, Berry AS, Jagust WJ, Cools R. Eur J Neurosci (2018) 47(9): 1081-1086


Treatment of reward sensitive to the pharmacological manipulation of dopamine:

Amplified Striatal Responses to Near-Miss Outcomes in Pathological Gamblers.

Sescousse G, Janssen LK, Hashemi MM, Timmer MHM, Geurts DEM, ter Huurne NP, Clark L, Cools R. Neuropsychopharmacology (2016) 41(10): 2614-2623

Abnormal modulation of reward versus punishment learning by a dopamine D2-receptor antagonist in pathological gamblers.

Janssen LK*, Sescousse G*, Hashemi MM, Timmer MHM, ter Huurne NP, Geurts DEM, Cools R. Psychopharmacology (2015) 232(18): 3345-3353.




the site of the lyon addictology hospital-university services


Processing reward 

The objectives of axis 1 are:

  1. better characterize brain mechanisms that underlie reward and motivation processes in healthy individuals, and

  2. of identify their dysfunction(s) through various psychiatric disorders, in particular addictions with or without substances.


For this, we use amulti-level approach, the study of neurotransmission to that of behaviour, as well as a variety of tools, from the brain imaging to the neuropsychology and  psychopharmacology.

Our long-term goal is to contribute to the development of a more personalized approach to addiction treatment.  

Main objective :
Investigate the relationship between reward processing, DA transmission and fronto-striatal connectivity

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