AXIS 3:
Regulation of emotions
The emotion regulation is a fundamental part of our daily lives, playing a key role in managing the environment, especially in the context of social interactions, and influencing our thoughts and behaviors. It is also a primary factor in psychiatric illness.
Axis 3 aims to disentangle theneurochemical, neural and cognitive mechanisms of emotion regulation in normal and pathological situations. In particular, our work assesses how stressful situations, affecting emotion regulation abilities through cortico-limbic networks, can lead to abnormal behaviors and, in subjects with high levels of vulnerability, psychiatric disorders such as psychotic crises, attempted suicide and drug addiction.
As in the other axes, the objective is to combine several levels of information (neuronal, neurochemical and cognitive but also genomic and transcriptomic) to explore emotional reactions through a variety of behaviors, from normal to abnormal.
General Purpose:
Establish the relationships between emotion regulation, DA transmission and cortico-limbic loops.
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Definition of emotional regulation:
Ability to respond to external emotional prompts in a socially appropriate manner.
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In most neuropsychiatric pathologies, deficits in emotional regulation have been observed, this includes hyper-reactivity to stress.
Key element in the transition to pathology.
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An abnormal acute stress response in subjects at risk (AD, cortisol)
We study the role of the prefrontal cortex
in emotional regulation.
